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Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference


May 4 - 5, 2019 / Stanford, CA

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The American Initiative in Mast Cell Diseases (AIM) is a network which will consist of Centers of Excellence and Reference Centers in the United States, Canada, Mexico, Central, and South America. This network will collaborate with the European Competence Network on Mastocytosis (ECNM), which has centers established throughout Europe.


AIM Conference


Join us May 4-5, 2019 at the Li Ka Shing Center on the campus of Stanford University School of Medicine for the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference.

This inaugural AIM Investigator Conference will bring together physicians from multidisciplinary specialties as well as laboratory researchers to highlight the latest advances in mast cell disease.   

Registration is required.  The deadline for registration is April 26, 2019.


About the Area


The Stanford University campus offers opportunities to experience art, history, sports, and outdoor activities.  More information about visiting the campus can be found on the school’s website.

For complete information on the area and all it has to offer, please visit
Destination Palo Alto.


Conference Schedule



7:30 - 8:10 am Registration

8:10 - 8:20 am Welcome/Introductions

8:20 – 8:50 am Keynote: What Can Normal Mast Cell Biology Tell Us About Mastocytosis?
Frank Austen, MD, Boston, MA

8:50 - 9:00 am Q&A

Session 1: Research Updates in Mast Cell Biology
Chairs: Dean Metcalfe, MD and Stephen J. Galli, MD

9:00 - 9:20 am Mast Cells as Sentinels of Innate Immunity
Stephen J. Galli, MD, Stanford, CA

9:20 - 9:40 am IgE and Non-IgE-Mediated Mast Cell Activation
Dean Metcalfe, MD, Bethesda, MD

9:40 - 10:00 am Single-Cell Characterization of Mast Cell Hyperplasia in Human Type 2 Inflammation
Daniel Dwyer, PhD, Boston, MA

10:00 - 10:20 am Experimental Models of Mast Cell Disease
Michel Arock, PharmD, PhD, France

10:20 - 10:40 am Siglec-8: Mast Cell Biology and Clinical Targeting
Bruce Bochner, MD, Chicago, IL

10:40 - 10:50 am Discussion Panel / Q&A

10:50 - 11:20 am Coffee Break

SESSION 2: Classification, Pathology and Molecular Biology
Chairs: Tracy George, MD and Peter Valent, MD

11:20 - 11:40 am WHO Classification of Mastocytosis in 2018
Peter Valent, MD, Austria

11:40 - 12:00 pm Bone Marrow Pathology in the Diagnosis of Mast Cell Disease
Tracy George, MD, Salt Lake City, UT

12:00 pm - 12:20 pm Extramedullary Mast Cell Disease
Hans-Peter-Horny, MD, Germany

12:20 - 12:40 pm Flow Cytometric Immunophenotyping Methods in Systemic Mastocytosis
Alberto Orfao, MD, PhD, Spain

12:40 - 1:00 pm Well-Differentiated Systemic Mastocytosis
Cem Akin, MD, PhD, Ann Arbor, MI

1:00 - 1:10 pm Discussion Panel / Q&A

1:10 - 2:10 pm Lunch 

SESSION 3: Mast Cell Activation
Chairs: Lawrence B. Schwartz, MD, PhD and Joseph Butterfield, MD

2:10 - 2:30 pm Biology of Tryptase and its Role as a Marker in Mast Cell Disease
Lawrence B. Schwartz, MD, PhD, Richmond, VA

2:30 - 2:50 pm Urinary Mediators in Mast Cell Diseases
Joseph Butterfield, MD, Rochester, MN

2:50 - 3:10 pm Mast Cell Activation Syndromes
Catherine Weiler, MD, PhD, Rochester, MN

3:10 - 3:30 pm Allergy and Anaphylaxis in Mast Cell Diseases
Patrizia Bonadonna, MD, Italy

3:30 - 3:50 pm Hereditary α-Tryptasemia
Jonathan Lyons, MD, Bethesda, MD

3:50 - 4:10 pm Role of Mast Cells in Neuroinflammation
Theoharis Theoharis, MS, MPhil, PhD, MD, Boston, MA

4:10 - 4:20 pm Discussion Panel / Q&A

4:20 - 5:00 pm Poster Board Walk and Coffee/Food Break

5:00 - 5:40 pm 2 Young Investigator Oral Presentations

5:40 - 5:45 pm Closing Remarks Day 1


Special Session: The ECNM Experience

8:10 - 8:40 am Lessons Learned from the ECNM Experience: A Roadmap for AIM
Peter Valent, MD, Austria

8:40 - 9:00 am The ECNM Registry
Wolfgang Sperr, MD, Austria

9:00 - 9:20 am Roundtable Discussion
Discussants: Peter Valent, MD, Austria; Wolfgang Sperr, MD, Austria; Michel Arock, PharmD, PhD, France; AIM Steering Committee

Session 4: Clinical Heterogeneity in Mast Cell Disease
Chairs: Mariana Castells, MD, PhD and Cem Akin, MD, PhD

9:20 - 9:40 am Skin Disease in Pediatric and Adult Systemic Mastocytosis
Melody Carter, MD, Bethesda, MD

9:40 - 10:00 am Gastrointestinal Manifestations of Mast Cell Disease
Matthew Hamilton, MD, Boston, MA

10:00 - 10:20 am Transplantation in Advanced Systemic Mastocytosis
Celalettin Ustun, MD, Chicago, IL

10:20 - 10:40am Looking for MCAS, Finding Immune Deficiency: Revisiting an Old Paradigm of Immune Dysfunction
Anne Maitland, MD, PhD, Tarrytown, NY

10:40 - 11:00 am PRO Instruments for Symptoms / QOL in Systemic Mastocytosis
Hanneke Oude Elberink, MD, PhD, The Netherlands

11:00 - 11:20 am New Prognostic Scoring Systems in Systemic Mastocytosis
Mohamad Jawhar, MD, Germany

11:20 - 11:30 am Discussion Panel / Q&A

11:30 am - 12:00 pm Coffee Break

SESSION 5: Treatment of Systemic Mastocytosis
Chairs: Melody Carter, MD and Deepti Radia, MD

12:00 - 12:20 pm Anti-Mediator Therapy in Mast Cell Diseases
Mariana Castells, MD, PhD, Boston, MA

12:20 - 12:40 pm Approved and Off-Label Treatment Approaches for Systemic Mastocytosis
Deepti Radia, MBBS, MRCPI, FRCPath, Msc Med Ed, UK

12:40 - 1:00 pm 2nd Generation Selective KIT D816V Inhibitors in Systemic Mastocytosis
Michael Deininger, MD, PhD, Salt Lake City, UT

1:00 - 1:20 pm Challenges in Pediatric Mastocytosis
Melody Carter, MD, Bethesda, MD

1:20 - 1:40 pm Future Trial Designs to Address Unmet Needs in Systemic Mastocytosis
Hanneke Kluin-Nelemans, MD, PhD, The Netherlands

1:40 - 2:00 pm NCCN Guidelines for Systemic Mastocytosis
Jason Gotlib, MD, MS, Stanford, CA

2:00 - 2:10 pm Discussion Panel / Q&A

2:10 - 2:20 pm Closing Remarks
Jason Gotlib & Cem Akin

Boxed Lunches to Go





Three major airports serve the San Francisco Bay area, including San Francisco International (SFO), San Jose Mineta International (SJC), and Oakland International (OAK).  Stanford is equidistant from the San Francisco and San Jose airports.

For general information on getting to San Mateo, airport transportation, and getting around town, please visit San Mateo County Silicon Valley Convention and Visitors Bureau.  


Parking is available in Parking Structure 5 on campus.  There is no charge to park on a Saturday or Sunday.  A map of the structure, with walking directions to La Ki Shing can be found here.




We have reserved a guest block of rooms at multiple area hotels for the nights of May 3 and May 4. When making your reservations please reference that you are part of the guest block for the “AIM Physician Meeting.”  

*Please make reservations by April 22, 2019.

Westin Palo Alto Hotel

Room Rate: $189/night
675 El Camino Real
Palo Alto, CA 94301

Phone: (650) 321-4422
Email: at 
Please contact our Group coordinator, Cheyenne Hulsey via email at in order to secure a room reservation at the group rate. She will need the following information:

1. Name
2. Arrival/Departure date
3. Address, phone and email address
4. Credit card number for guarantee.

Rosewood Sand Hill Menlo Park

Room Rate: $525/night
2825 Sand Hill Road
Menlo Park, CA 94025

(650) 561-1515

Sheraton Palo Alto Hotel

Room Rate: $149/night
625 El Camino Real
Palo Alto, CA 94301

(800) 325-3535
Via e-mail:
Reservations made via email must include the following: Guest Name, Arrival/Departure Date, Address, Phone # & Name of Group.
To guarantee a reservation, one must give a credit card number and expiration date.




The inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference will be held at Stanford University following The Mastocytosis Society, Inc. biennial conference for patients, caregivers and families impacted by mast cell diseases.  Sponsorship opportunities include promotional and marketing benefits at both conferences.

A limited number of registrations for sponsoring pharmaceutical companies is available.

For more information about sponsorship opportunities please contact


We acknowledge the generous support of the Inaugural AIM Investigator Conference




A poster reception will be taking place on Saturday, May 4th at the Li Ka Shing Center at 4:20 PM. The poster reception provides a forum for investigators to share their work related to Mast Cell Diseases. 

The AIM poster session is a forum for presentation of research findings in mast cell disease and should include at least some original new data not previously presented at a national or international meeting. Accepted abstracts will be considered for poster presentation.

Selection of abstracts for oral vs. poster presentation by young investigators/trainees will be made by the Scientific Program Committee. This committee, in conjunction with the Conference Fundraising Committee, will also identify ten physicians-in-training, each with a $1,000 travel award, totaling $10,000, and five $1,500 grants for non-US physicians and/or physicians-in-training in the Central American, South American and Canadian regions. Individuals will be selected (electronic, blinded process) for travel grants based on the merit of their scientific abstracts, quality and relevance to AIM’s core missions, and considerations of inclusiveness. Specifically, we will award one or more travel grants to under-represented minorities (URM) for this inaugural meeting.

The presenting author of an accepted abstract must register for the conference. Accepted abstracts will be posted on the AIM web site.

After the abstract submission deadline, abstracts may not be revised or resubmitted.

The submission deadline has passed. Abstracts are no longer being accepted.


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